{"id":8511,"date":"2022-11-04T05:54:24","date_gmt":"2022-11-04T10:54:24","guid":{"rendered":"https:\/\/va.esys.uk.com\/wordpress\/?p=8511"},"modified":"2022-12-26T10:20:14","modified_gmt":"2022-12-26T15:20:14","slug":"neroli-and-anticancer-activity","status":"publish","type":"post","link":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2022\/11\/04\/neroli-and-anticancer-activity\/","title":{"rendered":"Neroli and Anti-Cancer Activity"},"content":{"rendered":"<p><img data-attachment-id=\"8576\" data-permalink=\"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2022\/11\/04\/neroli-and-anticancer-activity\/chart\/\" data-orig-file=\"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?fit=869%2C398&amp;ssl=1\" data-orig-size=\"869,398\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"chart\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?fit=869%2C398&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?fit=869%2C398&amp;ssl=1\" decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-8576\" src=\"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?resize=869%2C398&#038;ssl=1\" alt=\"\" width=\"869\" height=\"398\" srcset=\"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?w=869&amp;ssl=1 869w, https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2022\/11\/chart.jpg?resize=768%2C352&amp;ssl=1 768w\" sizes=\"(max-width: 869px) 100vw, 869px\" data-recalc-dims=\"1\" \/><\/p>\n<h1><span style=\"color: #333399;\">neroli essential oil in <a style=\"color: #333399;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0031942221002508?via%3Dihub\">scientific research<\/a><\/span><\/h1>\n<ul>Highlights<\/p>\n<li><span style=\"color: #333399;\">Nerolidol induces G1 phase arrest to reduce the proliferation of rat leiomyoma cells;<\/span><\/li>\n<li><span style=\"color: #333399;\">The inhibitory effect of nerolidol depends on reactive oxygen species generation;<\/span><\/li>\n<li><span style=\"color: #333399;\">Nerolidol induces DNA damage in rat leiomyoma cells;<\/span><\/li>\n<li><span style=\"color: #333399;\">Nerolidol reduces the activation of ATM\/Akt kinases;<\/span><\/li>\n<li><span style=\"color: #333399;\">Inhibition of ATM mimics the effect of nerolidol in leiomyoma cells.<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p><span style=\"color: #333399;\">Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol), a sesquiterpene alcohol present in aromatic essential oils of numerous plants, has been reported to possess anticancer activity.<\/span><\/p>\n<p><span style=\"color: #333399;\">The potential therapeutic effect of nerolidol on uterine fibroids (UF), the most common benign tumor of the uterus worldwide, is unknown. In this study, we examined the anti-UF potential of nerolidol in ELT3 cells, a rat leiomyoma cell line widely used as an in vitro model, to identify the potential therapeutic agents for UF.<\/span><\/p>\n<p><span style=\"color: #333399;\">We observed that treatment with cis- or trans-nerolidol inhibited cell proliferation in a dose-dependent manner and induced cell cycle arrest in the G1 phase, which was accompanied by reduction in Akt phosphorylation and downregulation of cyclin D1, cyclin-dependent kinase 4 (CDK4), and CDK6 protein expression.<\/span><\/p>\n<p><span style=\"color: #333399;\">The proliferation-inhibiting activity of nerolidol correlated with the generation of intracellular reactive oxygen species (ROS), which was suppressed by N-acetyl-l-cysteine, a ROS inhibitor. Nerolidol treatment also increased the percentage of cells for which tail moment could be calculated using an alkaline comet assay, and induced p-\u03b3H2AXser139 expression, which indicated induction of DNA damage.<\/span><\/p>\n<p><span style=\"color: #333399;\">We also observed downregulation of ATM and its phosphorylation after nerolidol treatment; furthermore, treatment with KU-55933, an ATM kinase inhibitor, mimicked the inhibitory effects of nerolidol treatment on cell proliferation and Akt phosphorylation. In conclusion, nerolidol displayed anti-UF activity in a leiomyoma cell model via ROS-induced DNA damage and G1 phase cell cycle arrest by inhibiting the expression and activation of the ATM\/Akt pathway. Our data suggests that nerolidol is a potential therapeutic agent for UF.<\/span><\/p>\n<p><span style=\"color: #333399;\"><a style=\"color: #333399;\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0031942221002508?via%3Dihub\">see more in the research article<\/a><\/span><\/p>\n<p><span style=\"color: #333399;\">and look Maharishi Aroma therapy video about Neroli Essential Oil<\/span><br \/>\n<span style=\"color: #333399;\"><a style=\"color: #333399;\" href=\"https:\/\/vedaroma.com\/video\/neroli.html\">(link for video)<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>neroli essential oil in scientific research Highlights Nerolidol induces G1 phase arrest to reduce the proliferation of rat leiomyoma cells; The inhibitory effect of nerolidol depends on reactive oxygen species generation; Nerolidol induces DNA damage in rat leiomyoma cells; Nerolidol.. <a href=\"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2022\/11\/04\/neroli-and-anticancer-activity\/\">Read More<\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[4,85],"tags":[],"jetpack_publicize_connections":[],"aioseo_notices":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7sgRs-2dh","jetpack-related-posts":[{"id":6454,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2019\/06\/04\/frankincense-oil-kills-chemo-resistant-cancer-cells-without-damaging-healthy-cells\/","url_meta":{"origin":8511,"position":0},"title":"Frankincense Oil Kills Chemo-Resistant Cancer Cells Without Damaging Healthy Cells","date":"June 4, 2019","format":false,"excerpt":"frankincense targets cancer cells... ...leaves healthy cells intact and boosts white blood cell count to help cancer from coming back. A series of emerging studies are finding frankincense has the impressive ability to cause cancer cells to \u201ccommit suicide,\u201d without harming healthy cells. Additionally, it stimulates the rapid production of\u2026","rel":"","context":"In &quot;Products&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2019\/06\/frankincense-tree.jpg?fit=627%2C396&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1216,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2016\/08\/07\/the-healing-properties-and-application-of-neroli-essential-oil\/","url_meta":{"origin":8511,"position":1},"title":"The Healing Properties and Application of Neroli Essential Oil.","date":"August 7, 2016","format":false,"excerpt":"Video series \u2013 Neroli \u2013\u00a0tranquilizer enjoy our\u00a0weekly video series Aroma Therapy series # 25: Learn in this video about the healing properties and application of Neroli Essential Oil. Subscribe to our Newsletters to watch this video series. Purchase or learn more about Neroli Essential Oil\u00a0on our\u00a0EU Shop\u00a0or USA Shop An\u2026","rel":"","context":"In &quot;Beauty&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2016\/08\/Neroli-thmneil.jpg?fit=1200%2C669&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1835,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2017\/04\/21\/the-sunny-spirit-of-citrus-essential-oils\/","url_meta":{"origin":8511,"position":2},"title":"The Sunny Spirit of Citrus Essential Oils","date":"April 21, 2017","format":false,"excerpt":"\u00a0 sun-loving citrus fruit are abundant in essential oils. Scratch the peel of an orange or lemon and sniff. That\u2019s the scent of citrus essential oils. Citrus are brightly colored fruit that are grown in areas with abundant sunshine. Distill these plants down to their essential oils, and their sunny\u2026","rel":"","context":"In &quot;Education&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/img.theepochtimes.com\/n3\/eet-content\/uploads\/2015\/02\/15\/shutterstock_95061862.jpg?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1507,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2017\/10\/08\/sundays-answer-to-saturdays-quiz-question\/","url_meta":{"origin":8511,"position":3},"title":"Sunday\u2019s Answer to Saturday\u2019s Quiz Question","date":"October 8, 2017","format":false,"excerpt":"Quiz answer: There are three different VedAroma Essential Oils produced from the plant called: Citrus Aurantium The three VedAroma \u00a0Essential Oils produced from\u00a0Citrus Aurantium\u00a0are: VedAroma Neroli Essential Oil, VedAroma Petitgrain, bigarade Essential Oil, and VedAroma Orange, bitter Essential Oil The sweet fragrances of all these three Essential Oils are uplifting,\u2026","rel":"","context":"In &quot;Entertainment&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2015\/09\/screen-shot-2015-02-28-at-3-29-03-pm2.png?fit=236%2C286&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":6552,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2019\/09\/02\/testimonial-floral-waters\/","url_meta":{"origin":8511,"position":4},"title":"Testimonial: Hydrolates &#8211; Floral Waters","date":"September 2, 2019","format":false,"excerpt":"traveller sized: natural floral waters \"While I enjoy trying different all-natural and organic skin care products, I really enjoyed including Traveller Flower Water Synergy in my skin care routine. It's a wonderful product helping to keep my skin consistently clear, smooth and soft and healthy and radiant during the travels\u2026","rel":"","context":"In &quot;Products&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/va.esys.uk.com\/wordpress\/wp-content\/uploads\/2019\/06\/hydrlates.png?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":3917,"url":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/2018\/05\/13\/happy-mothers-day\/","url_meta":{"origin":8511,"position":5},"title":"Happy Mother&#8217;s Day","date":"May 13, 2018","format":"video","excerpt":"enjoy gorgeous scents Mothers deserve the best. Treat yourself or your Mom to a lovely perfume or essential oil this year. Above in Video: Pure and Natural,\u00a0Mohini (50 ml),\u00a0Eau de Parfum The rich and exotic fragrances of Osmanthus, Blue Lotus petals, and delicate Neroli blossoms \u2014 Eau de Parfum in\u2026","rel":"","context":"In &quot;Family&quot;","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/posts\/8511"}],"collection":[{"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/comments?post=8511"}],"version-history":[{"count":10,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/posts\/8511\/revisions"}],"predecessor-version":[{"id":8577,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/posts\/8511\/revisions\/8577"}],"wp:attachment":[{"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/media?parent=8511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/categories?post=8511"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/va.esys.uk.com\/wordpress\/index.php\/wp-json\/wp\/v2\/tags?post=8511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}